How might the urban geography of cities have looked like prior to the Renaissance

Why did noli me tangere have such a big impression on the narrator?

"the plan of removing the aboriginal people who yet remain within the settled portions of the united states . . approaches its consummation. . an extensive region . . has been assigned for their permanent residence. it has been divided into districts and allotted among them. many have already removed and others are preparing to go. . " removal of southern indians to indian territory, 1835 this passage is most closely related to a) imperialism. b) the civil war. c) westward expansion. d) the french indian war.

Which number on the map indicates the farthest reaches of alexander conquests?