How did global contact create social and cultural change during the Renaissance in Italian city-states?

First I'll explain what a city-state was. It is, simply put a city that is independent from any state or country. The three main ones were Milan, Venice, and Florence. They conquered the other city states. They still exist today though they are now cites within Italy.  

Explanation:

Italian city-states trading during the late Middle Ages set the stage for the ... covered the Mediterranean and beyond were also major conduits of culture ... reached 20%, making it the most urbanized society in the world at that time) ... linguistic studies of the Renaissance, in newly created academies in Florence and Venice.

Explanation:

the nationalists wanted a strong central government so the new country wouldn't fall apart.

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d) the constitution rights of native americans and their right to self-government on reservations