Read the research question for an informative essay about the Mississippi River long ago. How did the geography of the Mississippi River Delta affect settlement in this region?

Which sentence is the most effective follow-up question?

Where did people primarily settle in this region?
What is life like on the Mississippi River Delta today?
How did settlement compare in other parts of the South?
What was settlement like along the Ohio River long ago?

"but let us admit texas, and we shall place the balance of power in the hands of the texans themselves. they, with the southern states, will control the policy and the destiny of this nation; our tariff will then be held at the will of the texan advocates of free trade. are our friends of the north prepared to deliver over this great national policy to the people of texas? " - rep. joshua giddings, ohio, may 21, 1844 this quote points to what major issue in the years leading up to the civil war?