Which of these political leaders contributed MOST significantly to the framing of the U. S. Constitution? A James Madison
B. John Adams
C. Thomas Jefferson
D. Patrick Henry

The original states, except Rhode Island, collectively appointed 70 individuals to the Constitutional Convention. A number of these individuals did not accept or could not attend, including Richard Henry Lee, Patrick Henry, Thomas Jefferson, John Adams, Samuel Adams, and John Hancock. In all, 55 delegates attended the Constitutional Convention sessions, but only 39 actually signed the Constitution. The delegates ranged in age from Jonathan Dayton, aged 26, to Benjamin Franklin, aged 81, who was so infirm that he had to be carried to sessions in a sedan chair.

I think it is John Adams