What factors played a role in Italy's decline after 1500?

Italy was not a unified nation in the 1500's but a series of regions and city-states which shared the same peninsula in the Mediterranean Sea. The power/domination of the Church of Rome had lost influenc.

or

when trade routes shifted  it lost its monopoly on trade in the east. War and foreign domination left it weak and divided

the constitution gives congress the power to regulate commerce "among" the several states.

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