The invention of the cotton gin negatively affected native americans living in the south because it led to
a. a decrease in labor.
b. a war between tribes.
c. the loss of their land.
d. the violation of important treaties.

The correct answer that would best complete the given statement above would be the second option, option B: A WAR BETWEEN TRIBES. The invention of the cotton gin negatively affected Native Americans living in the south because it led to a war between tribes. Hope this answer helps.