"This spring, also, those Indians that lived about their trading house there fell sick of small pox, and died most miserably" What was the primary cause of this situation?

This spring also, these Indians that lived about their trading house there, fell sick of the small pox and died most miserably; for a sorer disease cannot befall them, they fear it more than the plague. ... And then being very sore, what with cold and other distempers, they die like rotten sheep.

Explanation:

worcester v. georgia, legal case in which the u.s. supreme court on march 3, 1832, held (5–1) that the states did not have the right to impose regulations on native american land. andrew jackson refused to enforce the ruling, the decision form the basis for most subsequent indian law in the united states.