2. Which empire in Asia threatened the net work of spice and slave trade to the Middle East? *

tenochtitlan (also spelled tenochtitlán), located on an island near the western shore of lake texcoco in central mexico, was the capital city and religious centre of the aztec civilization. the traditional founding date of the city was 1345 ce and it remained the most important aztec centre until its destruction at the hands of the conquering spanish led by hernán cortés in 1521 ce, which led to the final collapse of the aztec empire.

the answer is a or the 1st option:  

the heads of the inquisition felt it was offensive, unfocused, and blasphemous.

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companies passed on production and transportation costs to consumers