Following the treaty of paris in 1763, what event left the vast interior of the continent open for americans to colonize?

Following the Treaty of Paris in 1763, the event that  left the vast interior of the continent open for Americans to colonize was france being removed from North America.

The Treaty of Paris of 1763 put an end to the French and Indian War/Seven Years' War between Great Britain and France, as well as their respective allies.

It was signed on 10 February 1763 by the kingdoms of Great Britain, France and Spain, with Portugal in agreement, following Great Britain's victory over France and Spain during the Seven Years' War.

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