How did the arrival of european settlers on the east coast of north america impact the native americans ?

Native Americans for the most part were not friendly. Who could blame them, since colonists were pretty much invading their territory, and they were kinda cruel. Probably due to fear or caution of native Americans.

Nevertheless, the native Americans were raiding colonists and their homes. This is probably the answer you are looking for. In turn, colonists took matter to their own hands and also hurt the native Americans.

Both sides' distrust of each other escalated to the point where native Americans eventually were nearly wiped out during the expansion of European colonists.

The Native Americans for the most part were peaceful and willing to trade with the settlers. There were some issues, but not a ton. The settlers brought some of their crops that were unknown to the Indians and the Indians showed them there's.
The spread of diseases that both sides were not used to was evident, and sooner or later the Native people would be forced into slave labor by other settlers.