How did the interaction and conflict between english settlers and indians affect both parties, and contribute to developments that neither grough sought?

The Powhatan Indians were not treated fairly by the English settlers. That's why they tried to rise against these European settlers. This rise was known as  the first Anglo-Powhatan war and the Indians were defeated. They then tried to rise again in the second Anglo-Powhatan war, however, they were defeated again.

After the second defeat, there was nearly no hope for peace to be established between the Indians and the English settlers.

However, eventually, a peace treaty was signed. This treaty mainly resulted in a reluctant coexistence between both the Indians and the English settlers.
This peace lasted until the Powhatan fell to the three D's where the diseases that came from Europe killed them.

Their military was also disorganized and they were disposals in the Europeans view as they served no economic purpose. These two reasons eventually led to their downfall.

On the other side, Indian attacks as well as Indian starvation led to the death of many European settlers.