An immediate effect of the voyage of Vasco de Gama was the A.
Beginning of direct trade between Portugal and India.
B.
Growth of strong nations in Europe.
C.
Discovery of rich gold kingdoms in Africa.
D.
European Exploration of America.

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Explanation:

john locke is most associated with the idea of consent of the governed which is the idea that the government is only valid if it has the consent of the people who are being governed.

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confederacy: supported slavery, believed states should be able to nullify federal laws, supported low tariffs

union: everything else