How did the doctrine of nullification uphold the founding principles

The way how Doctrine of Nullification uphold the founding principles is that it was based on the principle of federalism. The Doctrine was never included in US Constitution or any papers that will show its relation to the structure of the federal government but the main ideas were based on federalism.
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Cherokee  removal, part of the trail of tears, refers to the  forced  relocation between 1836 and 1839 of thecherokee  nation from  their lands ingeorgia, south carolina, north carolina, tennessee, texas, and alabama to the indian territory (present day oklahoma)  in  the thenwestern united states, and the resultant deaths