Why is mecca islam’s holiest city? what is expected of all muslims at some point during their lifetime?

Yes

Perform  pilgrimage

Explanation:

The origin of Islamism focused on the greatness of prophet Mohammed. One of the well-documented theories state that he was fleeing a revolt and resorted to rest and find refugee in Mecca. Thus, the place ultimately became known as the Holy City.

In the Islam faith, the adherents are required to perform the pilgrimage known as the Hegira. In this phase, the believers go to the city of Mecca once in their lifetime to pay their respects to the Holy City. They lie with their feet towards the city. Some are required to go around the place seven times in order to receive a blessing from Allah.

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ok sorry the answer is a. by their religion