How did european trade routes in the eastern hemisphere change after the 16th century

The European trade routes to the East changed from the land based system like the Silk Road into the sea based system that travels either westward or southward to east. This is because the lost of the trade routes in the land due to the conflict and wars forced the Europeans to create a new route through the sea and this is the time that theory the world is round is proven and is taken into consideration for making a new trade route.

I’m pretty sure it’s 4, you can check on the calculator