A double‑blind, randomized comparative experiment compared the effect of the drug lorcaserin and a placebo on weight loss in overweight adults. All subjects also underwent diet and exercise counseling. The study reported that after one year, patients in the lorcaserin group had an average weight loss of 5.8 kilograms (kg), while those on the placebo had an average weight loss of 2.2 kg. The study wanted to determine if there was a significant difference between the two groups and resulted in a P-value < 0.001.