According to CDC estimates, more than 2 million people in the United States are sickened each year with antibiotic‑resistant infections, with at least 23,000 dying as a result. Antibiotic resistance occurs when disease‑causing microbes become resistant to antibiotic drug therapy. Because this resistance is typically genetic and transferred to the next generations of microbes, it is a very serious public health problem. Of the three infections considered most serious by the CDC, gonorrhea has an estimated 800,000 cases occurring annually, with approximately 30% of those cases resistant to any antibiotic. Suppose a local health clinic sees 40 cases. The exact binomial probability that 15 or more cases are resistant to any antibiotic is 0.193 .