Certain drug cannot be taken by mouth because the entire dose of the drug is destroyed in the liver before it reaches the general circulation. explain why these same drugs can be given by injection, either intravenously or intramuscularly.

The correct answer would be that so drugs can act directly on targeted organs through the bloodstream or in the muscle of a particular organ.

Explanation

Certain drugs are administered by injection because they can not be taken oral mode as the entire dose of the drug is destroyed in the liver before reaching the circulation. Injections are suspension or liquid, injected into a vein, organ, or tissue as per the requirement or the best place to get it in circulating.  

The mode of administration of injection can be intradermal, intramuscular, in some cases intracardiac or brain intracerebral so the drug can directly reach to targeted organ or indirect circulation.

Thus, the correct answer is that so drugs can act directly on targeted organs through the bloodstream or in the muscle of particular organs.

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