9. What is meant by the phrase first-pass effect?

The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation.

to take away from

explanation:

probably since the potency of the cocaine, not a lot, but i've never done any research on cocaine so i wouldn't know, but i would also guess it would determine on the gap between sniffs or if you did it all at once, so i really don't know.