Mark is a nursing researcher who wants to study how nurses interact with paperwork at different hospitals. He starts with a protocol where the questions focus on the emotional impact that bureaucracy has on the nursing staff. After weeks of talking with nurses and looking over data, Mark realizes that the topic is dominated with discussions of interactions with supervisors and administrators. He re-writes his protocol to focus on interpersonal conflict, rather than emotional impact. Is it acceptable for Mark to change his research questions and protocol in the middle of a study?