Derive the expression for the apparent equilibrium constant (Kapp) for the folding of MKU in terms of K1 and K2, where Kapp

The question is incomplete. The complete question is :

In the native state, myokinase exists in two distinct conformations (MK1 and MK2).  It unfolds to the unfolded state (MKU) only from MK2.

K1 K2

MK1 ⇄ MK2 ⇄ MKU

Derive the expression for the apparent equilibrium constant (Kapp) for the folding of MKU in terms of K1 and K2, where Kapp = ( [MK1] + MK2] ) / [MKU].

Solution :

Derive the expression for the apparent equilibrium constant :

 ............(i)

Divide by in both numerator and the denominator.

 ................(ii)

Therefore the required expression is :

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