Denise asks why no one in her family will ever tell her how her grandfather died. finally, she learns that he died from a sexually transmitted disease that led to paralysis, psychosis, and blindness. most likely, he died from:

He died from "syphilis".

The primary indication of syphilis is a little, effortless sore. It can show up on the sexual organs, rectum, or inside the mouth. This sore is known as a chancre. Individuals frequently neglect to see it immediately. 
Syphilis can be trying to analyze. Somebody can have it without demonstrating any side effects for a considerable length of time. Notwithstanding, the prior syphilis is found, the better. Syphilis that remaining parts untreated for quite a while can make real harm vital organs, similar to the heart and cerebrum.

Hamlet's fourth soliloquy is probably his most famous one - "to be or not to be."it is rather different from his previous soliloquies because now he is contemplating something that didn't come up before - suicide. he is thinking whether it is worth it to fight to find his father's murderer when in the end all of them are going to die, so why not die sooner than later. he is contemplating if he should go on fighting or just kill himself and end it all, which is why this soliloquy in particular is rather depressing, hesitant, and gives a deeper insight into hamlet's madness.