A3-year-old child exhibited some early indication of turner syndrome, which results from a 45,x chromosome composition. karyotypic analysis demonstrated two cell types: 46,xx (normal) and 45,x. propose a mechanism for the origin of this mosaicism.

The answer is mitotic nondisjunction of X Chromosomes.

Explanation:

Nondisjunction is a type of error that occurs resulting in daughter cells with chromosome numbers that are abnormal (aneuploidy). Due to the error in chromosome numbers, it gives rise to conditions such as Down Syndrome (Trisomy 21) and Turner Syndrome (Monosomy X). Nondisjunction can be caused by;

1. Failure of separation to occur in a pair of homologous chromosome during meiosis I.

2. Failure of separation between sister chromatids in Meiosis II.

3. Failure of separation between sisters chromatids in mitosis.

This gives the 45,X in Turner syndrome. The other X chromosome is partly or completely missing. Hence, the female is born with only one X chromosome.

the anti federalists was a movement that was opposed to the creation of a us federal government. although they were not as organized as the federalists, they also had a large group of leaders, especially in state politics.

the statement "now, in a large extended country, it is impossible to have a representation, possessing the sentiments, and of integrity, to declare the minds of the people” represents the concerns of the anti federalists.

they strongly believed that the federalists were representing the interests of aristocratic elements of society at the expense of the majority of ordinary people, who lived in a rural society.

their fear for the creation of a strong federal government and the president’s power of veto in their opinion would create a tyrannical rule that would dominate the people. they defended the importance of restraining the government’s power towards people at any cost.