In the context of substance use, addiction refers to cases in which people have struggled to control drug use and have suffered serious negative consequences from that use.

In the context of substance use, addiction refers to cases in which people have struggled to control drug use and have suffered serious negative consequences from that use is a TRUE statement.

Explanation:

The addiction to a particular substance often leads to serious disorders that eventually culminate in permanent health issues. Once an individual gets addicted to any particular substances, both continuing the addiction and withdrawing from the addiction becomes highly problematic from the point of view of health as it tends to have adverse effects on both physical and mental health.