The use of , a mildly hallucinogenic but not physically addictive drug made from a cactus bud, goes back for centuries among Native Americans in the Southwest.

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Risk of harm in social and behavioral sciences generally fall in three categories, which are: breach of confidentiality, loss of autonomy, and study proceduresstudy procedures, breach of confidentiality, and loss of employmentinvasion of privacy, adverse reaction to study drug, and discriminationinvasion of privacy, breach of confidentiality, and study procedures