What impact did european contact have on the native american population between 1500 and 1620

The manufacturing and trading because back then they did not have a right to come into the european countries.

Ghana, first of the great medieval trading empires of western africa (fl. 7th–13th century). it was situated between the sahara and the headwaters of the sénégal and niger rivers, in an area that now comprises southeastern mauritania and part of mali.