Which two factors of a molecule determine whether or not it can cross the membrane?

Charge & Size

Explanation:

The smaller the particles, the easier they can diffuse through the cell membrane because they can pass through the channels of the cell membrane,

The lipid layer of the cell membrane  is hydrophobic hence‘hates’ charged molecules. Polar or charged molecules will need special channels with trans-membrane proteins to facilitate their movement

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hydroxyl -oh

alcohols, always polar, can form hydrogen bonds with h2o molecules

carboxyl -cooh  

cargoxylic acids, has acidic properties which is a source of hydrogen ions, found in cells in ionized for with a charge of oh-1

carbonyl > co

ketone if within skeleton, aldehyde if group is at the end of skeleton, k & a may be structural isomers, it determines 2 sugars (ketose & aldose)

amino -nh2

amines, acts as a base, it can pick up h+ ions from surrounding solution, ionized with charge of 1+

methyl ch2

addition to rna/dna affects and gene expression

phosphate -opo3 ²⁻

organic phosphates, contributes to negative charge to, molecule that it is a part of, and potential to react with h20

sulfhydryl -sh

thiols, cross-linking stabilize the protein, and it is structure