Biology, 19.10.2019 03:20 KieraKimball
Botulinum toxin is produced by clostridium botulinum, a gram-negative bacterium. the toxin actually consists of 7 related toxins, types a, b, c1, d, e, f and g. the toxin is synthesized as a protoxin of 150 kda, which is proteolytically cleaved to a light (l) and heavy (h) chains that remain linked by a disulfide bond. nerve terminals have receptors for both l and h chains. the l-chain is transported across the nerve terminal membrane by endocytosis. these l chains are metaloproteinases -proteases that require metal ions for activity. the l-chain binds zn2+, and it proteolytically degrades several proteins that make up the snare complex. a) what do you suppose happens when botulinum toxin is injected near the neuromuscular junctions? b) from this conclusion, what do you suppose the basis for botox injections?
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Botulinum toxin is produced by clostridium botulinum, a gram-negative bacterium. the toxin actually...
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