In a cell with defective chaperones, Question 14 options: proteins would not be able to exit the ribosome. the concentration of misfolded proteins would be higher than normal. proteins would not be delivered to their appropriate cellular locations. ribosomes would not associate with the endoplasmic reticulum.

the concentration of misfolded proteins would be higher than normal.  

Explanation:

Chaperones proteins are required for the correct protein folding of proteins. These proteins were first discovered in bacteria. The level of chaperones is increased under thermic stress conditions, it is for that reason that they are also known as heat shock proteins (Hsp). For example, Hsp70 is a chaperon protein constitutively expressed under stress conditions that is involved in the folding of protein precursors and the refolding of misfolded proteins. In humans, Hsp70 is encoded by the HSPA1A gene, and its increased expression level is related to different health problems including neurodegenerative diseases, cerebral ischemia and epilepsy.

the cytokine-activated janus kinase (jak)-signal transducer and activator of transcription (stat) pathway has an important role in the control of immune responses. dysregulation of jak-stat signaling is associated with various immune disorders.