Enzymes are proteins that have a three dimensional shape that is specific to a particular substract. environmental conditions can change. the shape of protein

The enzyme will no longer be able to catalyze the reaction with the substrate

Explanation:

Enzymes usually have a very specific structure than holds the substrate molecules, facilitating the optimal environment for the reaction to proceed. This reduces the activation energy required to start the reaction.

If the shape changes, the substrate molecule will no longer properly fit. Therefore, the enzyme will not be able to catalyze the reaction.