With respect to climate change and natural selection acting upon a population of one species of frog in a tropical rain forest, mutations of DNA sequences of the frog genome that are inherited by offspring It is estimated by a wide body of scientists that in recent decades we have begun another mass extinction event on Earth. Amphibians in particular have been in decline, sometimes due to climate change, and they therefore provide a possible early sign of dramatic biodiversity change to come. With respect to climate change and natural selection acting upon a population of one species of frog in a tropical rain forest, mutations of DNA sequences of the frog genome that are inherited by offspring may have no effect at all, be beneficial, or be harmful. will primarily be harmful. will only speed the decline and extinction of the species. could either be beneficial or harmful.