What are the two means of moving large molecules across the cell membrane with energy

Passive Transport and Active transport

Hope this helps. I don't know if this is the answer you were looking for...

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

answer; ///(statins)/aka as hmg coa