During the course of administration of an investigational drug, the following events occurred: on day 7, subject 603 had an unexpected stroke that requires hospitalization; on day 15, subject 415 complained of nausea, vomiting, and headache relieved by aspirin; on day 21, subject 20 has brief dizzy spells upon trying to stand. which of these subject’s events meets the fda definition of "serious" and "unexpected" and would require the sponsor to file an ind safety report with the fda?

Sensory adaptation of cutaneous temperature receptors some types of sensory receptors, like pain receptors, will continue to transduce pain until the stimulus is removed. other sensory receptors may respond with an initial burst in production of action potentials, but will “adapt” and over time action potentials will cease. sensory adaptation occurs, for example, with olfactory receptors for smell. procedure have the subject place one hand in an ice bath while simultaneously placing the other hand in a warm water bath (@40oc). the subject should keep their hands in the designated baths for two minutes. after two minutes, remove both hands and place both hands in a room temperature water bath. record your observations review questions 1. describe how each hand felt after taking them out of the designated water baths and placing them into the room temperature water bath. 2. define sensory adaptation and relate it to what happened to the temperature receptors in the subject’s hands. 3. list and describe sensory receptors that adapt, and sensory receptors that do not.

Jason pressures emmanuel to be a gang member. which choice is the best way emmanuel can respond? tell jason he is not interested in joining. ignore jason and brush off what he says. lighten the mood by changing the subject. keep quiet and continue listening to jason.

Choose all answers that apply. what is true about resistance training