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Before the first Creek migration there were only about one hundred American Indians in Florida because

They already moved because of the threat from the Settlers.

Explanation:

Florida was a very popular region among the settlers. This territory possess a perfectly warm climate and excellent soils that make it easy to grow various types of crops.

This made a lot of people move here to opened up plantations/farms. As the number of settlers increased, Native Americans faced bigger threats of engaged in the conflict /being killed. This forced them to spread out and move to other territories before the creek migration even began.

nativists tried to get rid of the immigrants as they thought they were going to ruin the u.s.  

answer; i believe the answer is (mesopotamia); modern day