A combination of KM and kcat with which relative values is indicative of the lowest catalytic efficiency for an enzymatically catalyzed reaction?
a. A high Km and a low kcat
b. A high Km and a high kcat
c. A low Km and a high kcat
d. A low Km and a low kcat

option a

Explanation:

is turnover number. The turnover number is defined as the number of chemical conversions by single enzymatic site per second.

K_m is Michaelis-Menten constant used in the study of kinetics of enzyme catalyzed reaction.

The relationship between Michaelis-Menten constant and turnover number is as follows:

Here, [S] is substrate concentration, E0 is the initial enzyme concentration and v is the rate of enzyme catalyzed reaction.

Turn over no. () is present in nominator while K_m is present in denominator. Therefore for lowest catalytic efficiency, turnover ( ) should be low and Michaelis-Menten constant (K_m) should be high.

Therefore, among, given option a is correct.

people flirt to show their affection towards someone in a less forward way then telling. they want the other person to guess what they’re feeling to have the other person also start to like them

if you're asking what comes out, it's steam.